منابع مشابه
Targeting redox biology to reverse mitochondrial dysfunction
is general agreement that mitochondria play an important role in the aging process, but the role of mitochondrial oxidative stress remains controversial. Most previous work looking at mitochondrial oxidative stress has focused on damage to DNA, proteins, and lipids with age or in response to manipulation of cellular antioxidants. The interaction between oxidative damage and aging has been calle...
متن کاملTargeting Mitochondrial Dysfunction with L-Alpha Glycerylphosphorylcholine
BACKGROUND We hypothesized that L-alpha-glycerylphosphorylcholine (GPC), a deacylatedphosphatidylcholine derivative, can influence the mitochondrial respiratory activity and in this way, may exert tissue protective effects. METHODS Rat liver mitochondria were examined with high-resolution respirometry to analyze the effects of GPC on the electron transport chain in normoxic and anoxic conditi...
متن کاملTargeting mitochondrial dysfunction as in aging and glaucoma.
Neurons depend on their mitochondria for optimum function and become susceptible with age. Mitochondrial function is gradually impaired during aging because more electrons are converted to reactive oxygen species rather than being converted to ATP. Retinal ganglion cell mitochondria are additionally affected in glaucoma because of reduced oxygen delivery. Thus, targeting neuronal mitochondria t...
متن کاملTargeting mitochondrial dysfunction in lung diseases: emphasis on mitophagy
During mild stressful conditions, cells activate a multitude of mechanisms in an attempt to repair or re-establish homeostasis. One such mechanism is autophagic degradation of mitochondria or mitophagy to dispose damaged mitochondria. However, if stress persists beyond recovery then dysfunctional mitochondria can ignite cell death. This review article summarizes recent studies highlighting the ...
متن کاملTherapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia
Aberrant placentation generating placental oxidative stress is proposed to play a critical role in the pathophysiology of preeclampsia. Unfortunately, therapeutic trials of antioxidants have been uniformly disappointing. There is provisional evidence implicating mitochondrial dysfunction as a source of oxidative stress in preeclampsia. Here we provide evidence that mitochondrial reactive oxygen...
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2019
ISSN: 1759-4790,1759-4804
DOI: 10.1038/s41584-019-0332-5